TB-500

$40.00

Description

A 43-amino acid synthetic peptide associated with thymosin beta-4 and studied in preclinical models involving actin regulation, cell migration, tissue repair, and regenerative signaling pathways. Premium
Research Peptide.

Compound Information

Technical specifications


Molecular Profile

What Is TB-500?

Type
Thymosin beta-4–related peptide
Reference Compound
Thymosin beta-4
CAS Number
77591-33-4
Molecular Weight
Approximately 4,963 Da
Mature Peptide
43 amino acids
Active Fragment
Ac-SDKP
Primary Function
Actin binding



PubChem Database


Storage Requirements

Stability Information

Protect from light
Store desiccated
Avoid repeated freeze-thaw cycles


Lyophilized (powder)

-20°C

Long-term storage


Reconstituted

2-8°C

Use promptly

Sources & References

Peer-reviewed research and scientific resources

Expert Opinion on Biological Therapy

Thymosin β4: A Multi-Functional Regenerative Peptide—Basic
Properties and Clinical Applications

2012

DOI: 10.1517/14712598.2012.634793

PMID: 22074294

Goldstein AL, Hannappel E, Sosne G, Kleinman HK


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Annals of the New York Academy of Sciences

A Randomized, Placebo-Controlled, Single and Multiple Dose Study
of Intravenous Thymosin Beta-4 in Healthy Volunteers

2010

Human study

PMID: 20536472

Ruff D, Crockford D, Girardi G, Zhang Y


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PubMed Central

A Dose Response Study of Thymosin β4 for the Treatment of Acute
Stroke

Preclinical study

PMCID: PMC4177939

Experimental dose-response research in a rat embolic-stroke model


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Journal of Investigative Dermatology

Thymosin Beta-4 Accelerates Wound Healing

1999

PMID: 10469335

Malinda KM, Sidhu GS, Mani H, et al.


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Frontiers in Endocrinology

Progress on the Function and Application of Thymosin β4

2021

DOI: 10.3389/fendo.2021.767785

PMCID: PMC8724243

Xing Y, Ye Y, Zuo H, Li Y


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Nature

Thymosin β4 Activates Integrin-Linked Kinase and Promotes Cardiac
Cell Migration, Survival and Cardiac Repair

2004

DOI: 10.1038/nature03000

PMID: 15565145

Bock-Marquette I, Saxena A, White MD, DiMaio JM, Srivastava D


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Clinical Ophthalmology

Thymosin Beta-4 Ophthalmic Solution for Dry Eye: A Randomized,
Placebo-Controlled Phase II Clinical Trial

2015

Phase II

DOI: 10.2147/OPTH.S80954

PMID: 26056426

Sosne G, Ousler GW


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Neuroscience

Thymosin Beta-4 Improves Functional Neurological Outcome in a
Rat Model of Embolic Stroke

2010

PMID: 20627173

Xiong Y, Mahmood A, Meng Y, Zhang Y, Zhang ZG, Morris DC, Chopp M


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Nature

Thymosin Beta-4 Induces Adult Epicardial Progenitor Mobilization
and Neovascularization

2007

DOI: 10.1038/nature05383

PMID: 17108969

Smart N, Risebro CA, Melville AA, Moses K, Schwartz RJ, Chien KR,
Riley PR


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Journal of Neurosurgery

Treatment of Traumatic Brain Injury with Thymosin β4 in Rats

2011

DOI: 10.3171/2010.4.JNS10118

PMID: 20486893

Xiong Y, Mahmood A, Meng Y, Zhang Y, Zhang ZG, Morris DC, Chopp M


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Additional information

Dosage

10MG

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