MOTS-C

$35.00

Description

A 16-amino-acid mitochondrial-derived peptide studied in preclinical models
involving cellular metabolism, mitochondrial signaling, glucose regulation,
stress-response pathways, and energy homeostasis. Premium Research Peptide.

Compound Information

Technical specifications


Molecular Profile

What Is MOTS-C?

Type
Mitochondrial-derived peptide
Amino Acids
16
Sequence
MRWQEMGYIFYPRKLR
Molecular Weight
Approximately 2,174.6 g/mol
Molecular Formula


C101H152N28O22S2

Encoded In
12S rRNA region of mtDNA
Research Area
Mitochondrial signaling



Cell Metabolism (2015)


Storage Requirements

Stability Information

Protect from light
Store frozen until use
Avoid repeated freeze-thaw cycles


Lyophilized (powder)

-20°C

Long-term storage


Reconstituted

2-8°C

Use promptly


Handling

Minimize exposure

Keep cold during preparation

Sources & References

Peer-reviewed research and scientific resources

Cell Metabolism

The Mitochondrial-Derived Peptide MOTS-C Promotes Metabolic
Homeostasis and Reduces Obesity and Insulin Resistance

2015

DOI: 10.1016/j.cmet.2015.02.009

PMID: 25738459

Lee C, Zeng J, Drew BG, Sallam T, Martin-Montalvo A, et al.


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Nature Communications

MOTS-C Is an Exercise-Induced Mitochondrial-Encoded Regulator of
Age-Dependent Physical Decline and Muscle Homeostasis

2021

DOI: 10.1038/s41467-020-20790-0

Reynolds JC, Lai RW, Woodhead JST, Joly JH, Mitchell CJ, et al.


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Alzheimer’s Drug Discovery Foundation

MOTS-C Cognitive Vitality Research Evidence Report

2025

Scientific evidence report

Not peer reviewed

Cognitive Vitality research assessment


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Aging Cell

The Mitochondrial-Derived Peptide MOTS-C: A Player in
Exceptional Longevity?

2015

DOI: 10.1111/acel.12389

PMID: 26289118

Fuku N, Pareja-Galeano H, Zempo H, Alis R, Arai Y, et al.


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Physiological Reports

The Mitochondrial-Derived Peptide MOTS-C Is a Regulator of
Plasma Metabolites and Enhances Insulin Sensitivity

2019

DOI: 10.14814/phy2.14171

PMID: 31293078

Kim SJ, Miller B, Mehta HH, Xiao J, Wan J, et al.


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Biochemical and Biophysical Research Communications

Mitochondria-Related Peptide MOTS-C Suppresses
Ovariectomy-Induced Bone Loss via AMPK Activation

2016

DOI: 10.1016/j.bbrc.2016.05.135

PMID: 27237975

Ming W, Lu G, Xin S, Huanyu L, Yinghao J, et al.


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Pediatric Diabetes

Circulating MOTS-C Levels Are Decreased in Obese Male Children
and Adolescents and Associated with Insulin Resistance

2018

Human observational study

DOI: 10.1111/pedi.12685

PMID: 29691953

Du C, Zhang C, Wu W, Liang Y, Wang A, Wu S, et al.


View Source

Additional information

Dosage

10MG

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